Meeting 1st July 2020
 

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compbio.dagprojects:meetings20200701 [2020/07/02 19:58] (current)
jabbott created
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 +== Meeting 1st July 2020 ==
 +
 +Preset: Marek, William, James
 +
 +=== William ===
 +
 +Lego plots - will resent for approval. Also try placing legend at bottom and see how it looks.
 +
 +2 LCE genes share same protein change, which raised eyebrows.
 +
 +Good/bad bins for Eng/Irish distributed, based on LLR. 
 +
 +Extra data added to log logistic regression, controlled or not for FLG null, and with CI.
 +
 +SPRR3 did not make it into screened set of bins. Stuck with set of bins derived from automated detection, which has quite high p-value thresholds. Number of tests determined for every bin/group combination with further screen for having both groups in one population or all 4 groups. SPRR3 may not have been detected since is a deletion. Will try changing thresholds and see if it reappears.
 +
 +
 +=== Marek ===
 +
 +HipSci data - lots of interesting things. Some patients stand out as behaving differently and others clustering together.
 +
 +Sumolyation - Herves - eventually found a good database based on 2002 paper. Have algorithm for finding them in genome. Elements tend to group into entities. Did mapping to fake gtf file. Out of 100000-ish aroudn 8k herves have non-neglible counts. Stay low for a while then shoot up at end, which is what they were hoping for.
 +
 +=== James ===
 +
 +Running repeat finding across chr1 for EDC to load into jbrowse.
 +
 +HipSci - Transcriptomic data available for 260 cell lines, in some cases multiple lines from patients.  
 +
 +
 +
 +Miratul - new project on characterising mitochondrial ubiquityaltion sites. Arranging meeting
 +
  
 
compbio.dagprojects/meetings20200701.txt · Last modified: 2020/07/02 19:58 by jabbott
 
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